PUBLICATIONS

• Faricimab bei vorbehandelter neovaskulärer altersabhängiger Makuladegeneration (nAMD) : Studiendesign der prospektiven nichtinterventionellen Studie PASSENGER [Faricimab in previously treated neovascular age-related macular degeneration : Study design of the prospective noninterventional study PASSENGER].
  Heimes-Bussmann B, Bellenbaum R, Njoo C, Liakopoulos S, Schmitz-Valckenberg S, Zortel M, Rothaus K, Leemhuis J, Mussinghoff P, Lommatzsch A.
  Ophthalmologie 2025
• Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point-A Delphi Study: Classification of Atrophy Meetings Report 7.
  Wu Z, Sadda SR, Ach T, Blodi BA, Bottoni F, Chakravarthy U, Chew EY, Curcio CA, Ferris FL 3rd, Fleckenstein M, Freund KB, Grunwald JE, Holz FG, Jaffe GJ, Liakopoulos S, Lim TH, Monés JM, Pagliarini S, Pauleikhoff D, Pfau M, Rosenfeld PJ, Sarraf D, Schmitz-Valckenberg S, Spaide RF, Sparrow JR, Staurenghi G, Tufail A, Viola F, Guymer RH.
  Ophthalmol Sci 2025
• Interpretation of SD-OCT imaging data in real-life conditions versus standardized reading centre analysis in eyes with diabetic macular oedema or macular oedema secondary to retinal vein occlusion: 24-month follow-up of the ORCA study.
  Spital G, Schmitz-Valckenberg S, Müller B, Liczenczias E, Chang P, Heimes-Bussmann B, Ziemssen F, Liakopoulos S; ORCA study group.
  Graefes Arch Clin Exp Ophthalmol 2025
• Ellipsoid zone reflectivity as a functional imaging biomarker for age-related macular degeneration: a MACUSTAR study report.
  Liermann YN, Behning C, Isselmann B, Schmid M, Dunbar HMP, Luhmann UFO, Finger RP, Schmitz-Valckenberg S, Holz FG, Pfau M, Luu CD, Saßmannshausen M, Thiele S; MACUSTAR consortium.
  Sci Rep 2025
• The Spectrum of Functional, Structural, and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report.
  Terheyden JH, Holz FG, Behning C, Dunbar HMP, Schmitz-Valckenberg S, Tufail A, Schmid M, Crabb DP, Saßmannshausen M, Binns A, Hoyng CB, Zakaria N, Poor S, Moll KP, Cosette D, Martinho C, Batuca J, Cunha-Vaz J, Luhmann UFO, Leal S, Finger RP; MACUSTAR consortium.
  Ophthalmologica 2025
• Comparison Between Optical Coherence Tomography B-scan and En Face Imaging for the Diagnosis of Early Macular Atrophy in Age-Related Macular Degeneration.
  Cheng Y, Fleckenstein M, Schmitz-Valckenberg MS, Lu J, Liu Z, Herrera G, Gregori G, Wang RK, Rosenfeld PJ, Trivizki O.
  Degeneration. Am J Ophthalmol 2025
• Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting-lessons from the MACUSTAR study.
  Terheyden JH, Dunbar HMP, Schmitz-Valckenberg S, Behning C, Martinho C, Luhmann UFO, Saßmannshausen M, Lüning A, Miliu A, Aires ID, Basile PG, Batuca J, Schmid M, Moll KP, Zakaria N, Tufail A, Binns A, Crabb DP, Leal S, Finger RP, Holz FG; MACUSTAR consortium.
  Eye (Lond) 2025
• Geographic atrophy: Understanding the relationship between structure and function.
  Huang A, Wu Z, Ansari G, Von Der Emde L, Pfau M, Schmitz-Valckenberg S, Fleckenstein M, Keenan TDL, Sadda SR, Guymer RH, Cheung CMG, Chakravarthy U.
  Asia Pac J Ophthalmol (Phila) 2025
• Visual Loss in Geographic Atrophy: Learnings from the Lampalizumab Trials.
  Anegondi N, Steffen V, Sadda SR, Schmitz-Valckenberg S, Tufail A, Csaky K, Lad EM, Kaiser PK, Ferrara D, Chakravarthy U.
  Ophthalmology 2025
• Age-related macular degeneration: natural history revisited in geographic atrophy.
  Broadbent E, Künzel SH, Pfau M, Schmitz-Valckenberg S, Fleckenstein M.
  Eye (Lond) 2025
• Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report.
  de Vente C, Valmaggia P, Hoyng CB, Holz FG, Islam MM, Klaver CCW, Boon CJF, Schmitz-Valckenberg S, Tufail A, Saßmannshausen M, Sánchez CI; MACUSTAR Consortium.
  Transl Vis Sci Technol 2024  
• Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years.
  Saßmannshausen M, Döngelci S, Vaisband M, von der Emde L, Sloan KR, Hasenauer J, Holz FG, Schmitz-Valckenberg S, Ach T.
  Invest Ophthalmol Vis Sci 2024 
• Einsatz von künstlicher Intelligenz bei der geographischen Atrophie bei der altersabhängigen Makuladegeneration [Use of artificial intelligence in geographic atrophy in age-related macular degeneration].
  Chang P, von der Emde L, Pfau M, Künzel S, Fleckenstein M, Schmitz-Valckenberg S, Holz FG.
  Ophthalmologie 2024
• Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression.
  Zouache MA, Richards BT, Pappas CM, Anstadt RA, Liu J, Corsetti T, Matthews S, Seager NA, Schmitz-Valckenberg S, Fleckenstein M, Hubbard WC, Thomas J, Hageman JL, Williams BL, Hageman GS.
  Nat Commun 2024
• Association of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration.
  Künzel SH, Broadbent E, Möller PT, Lindner M, Goerdt L, Czauderna J, Schmitz-Valckenberg S, Holz FG, Pfau M, Fleckenstein M.
  Ophthalmol Retina 2024
• Der Einsatz künstlicher Intelligenz (KI) bei der altersabhängigen Makuladegeneration [Artificial intelligence (AI) in age-related macular degeneration].
  Holz FG, Schmitz-Valckenberg S.
  Ophthalmologie 2024
• Age-Related Macular Degeneration: A Review.
  Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U.
  JAMA 2024
• Age-related macular degeneration.
  Fleckenstein M, Keenan T D L, Guymer R H, Chakravarthy U, Schmitz-Valckenberg S, Klaver C C, Wong W T, Chew E Y.
  Nature Reviews Disease Primers 2021
• Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration Classification of Atrophy Meeting Report 4.
  Guymer R H, Rosenfeld P J, Curcio C A, Holz F G, Staurenghi G, Freund K B, Schmitz-Valckenberg S, Sparrow J, Spaide R F, Tufail A, Chakravarthy U, Jaffe G J, Csaky K, Sarraf D, Mones J M, Tadayoni R, Grunwald J, Bottoni F, Liakopoulos S, Pauleikhoff D, Pagliarini S, Chew E Y, Viola, Francesco, Fleckenstein M, Blodi B A, Lim T H, Chong V, Lutty J, Bird A C, Sadda S R.
  Ophthalmology 2020
• Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration.
  Holz F G, Sadda S R, Staurenghi G, Lindner M, Bird A C, Blodi B A, Bottoni F, Chakravarthy U, Chew E Y, Csaky K, Curcio C A, Danis R, Fleckenstein M, Freund K B, Grunwald J, Guymer R, Hoyng C B, Jaff, G J, Liakopoulos S, Mones, Jordi M, Oishi A, Pauleikhoff D, Rosenfeld P J, Sarraf D, Spaide R F, Tadayoni R, Tufail A, Wolf S, Schmitz-Valckenberg S.
  Ophthalmology 2017
• Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study).
  Schmitz-Valckenberg S, Sahel J-A, Danis R, Fleckenstein M, Jaffe G J, Wolf S, Pruente C, Holz F G.
  Ophthalmology 2016
• Geographic Atrophy Clinical Features and Potential Therapeutic Approaches.
  Holz F G, Strauss E C, Schmitz-Valckenberg S, Campagne M v L..
  Ophthalmology 2014
• Semiautomated Image Processing Method for Identification and Quantification of Geographic Atrophy in Age-Related Macular Degeneration.
  Schmitz-Valckenberg S, Brinkmann C K, Alten F, Herrmann P, Stratmann N K, Goebel A P, Fleckenstein M, Diller M, Jaffe G J, Holz F G.
  Investigative Ophthalmology & Visual Science 2011
• Fundus autofluorescence imaging - Review and perspectives.
  Schmitz-Valckenberg S, Holz F G, Bird A C, Spaide R F.
  Retina 2008
• High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration.
  Fleckenstein M, Issa P C, Helb H-M, Schmitz-Valckenberg S, Finger R P, Scholl H P N, Loeffler K U, Holz FG.
  Investigative Ophthalmology & Visual Science 2008
• Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration.
  Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl H P N, Schmitz-Valckenberg, S.
  American Journal of Ophthalmology 2007